Objective: To study the influence of pretreatment of transcutaneous electrical stimulation on the prevention of pain of propofol injection.Methods: 360 hysteroscopy elective examinations or treatment surgeries were randomly divided into control group (group C), sham transcutaneous electrical stimulation group (group F),transcutaneous electrical stimulation group(group T), each group has 120 patients.Group C doesnt do any treatment before surgery, 30mins before induction of anesthesia, group F and group T are selected to stimulate bilateral Hegu-Neiguan acupoint, group F detect the feeling flow while group T detect the tolerance flow,stimulation frequency was 2 / 100Hz, 30mins of stimulation time.After induction of anesthesia, propofol injection pain scores, hemodynamic parameters and adverse reactions were observed and recorded.Results:Among 360 tested patients, 324 cases finished.The results of comparison between hemodynamics of different patients whose venous access are divided into three groups are not the same.The nausea and vomiting after surgery different patients whose venous access are divided into three groups compared Group with GroupC and Group F was statistically significant (P<0.017);the incidence of moderate to severe pain in different groups was statistically significant (P<0.05);four point method of radial side end of the veins of the patients (P =0.048) and the elbow veins of the patients(p=0.001) were significant differences between the three groups in the groups,P=0.05 in the back of the hand vein patients, and the difference in the NRS pain scores between different vein in patients with the three groups was statistically significant differences (0.003, <0.001 and 0.013).Conclusions:Pretreatment of transcutaneous electrical stimulation can effectively reduce the severity of propofol injection pain and the incidence of pain on injection;it can also effectively reduce the incidence of postoperative nausea and vomiting and decrease the patients postoperative pain score.