Background :Long intergenic non-coding RNAs (lincRNAs) are a class of non-coding RNAs that are transcribed from intergenic regions of the genome.Despite receiving remarkable attentions,the biological roles of the majority of lincRNAs remain largely unknown due to diverse functions and molecular mechanisms.Recently developed ribosome profiling allows for a global measurement of RNAs associated with 80S ribosomes and suggests that many lincRNA are also bound by ribosomes.