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Objective Idiopathic membranous nephropathy (IMN) and membranous lupus nephritis (MLN) are two diseases alike in many aspects.We analyze their glomerular IgG subclasses deposition features for better understanding and trying to find another method to differ them pathologically.Method We conduct a retrospective study of 212 biopsy-proven IMN patients and 28 patients of membranous lupus nephritis (MLN) from Mar 2010 to Sep 2012.We examine and compare their glomerular IgG subclasses deposition by direct immunofluorescence.