Neonatal sepsis (NS), a common disorder for human, is recognized as a leading global public health challenge.A meta-analysis was performed to assess the accuracy of the Serum amyloid A (SAA) test for diagnosing NS.The studies that evaluated the SAA test as a diagnosis marker were searched from PUBMED, EMBASE, Cochrane library between January 1996 to October 2012.A total of seven studies including 663 neonates were included in our meta-analysis.Quality of each study was assessed by the quality assessment of diagnostic accuracy studies tool.The SAA test showed moderate accuracy of the diagnosis of NS both at the first suspicion of sepsis (Q*=0.90) and 8-96h after the sepsis onset (Q*=0.91), which is similar to the PCT and CRP test for the diagnosis of NS in the same period.Heterogeneity between studies was also explained by cut-off point, SAA assay, and age of included neonates.On the basis of our meta-analysis, therefore, SAA could be promising and meaningful in the diagnosis of NS.