Background: Over the past decade, breast cancer (BC) is found to be a highly heterogeneous disease with apparently different phenotypes and behaviors.Accordingly, clinical management largely depends on a variety of prognostic and predictive factors to arrive atan appropriate individual therapy for distinct subtypeof BC.Though molecular taxonomy has beendemonstrated to provide more accurate predictive and prognostic informationfor BC, its actual clinical role is limited by the availability of such technologies.