Osteoarthritis (OA) is a common degenerative joint disease that affects weight-bearing joints, including knee and hip.Progressive degeneration and loss of cartilage is a hallmark of OA, although the disease involves the entire joint, including subchondral bone and synovium.Currently available pharmacological OA treatments can provide temporary pain relief, but offer no structural benefit.There is a great unmet need for disease-modifying OA drugs (DMOADs) that could slow, halt, or reverse the progressive course of the disease and thus convey long-term symptomatic benefit.