Purpose: Bacterial invasion and epithelial downgrowth with pocket formation are still severe clinic challenges for transcutaneous implants,and both have closely connections with a lack of stable biological seal around transcutaneous parts.Dermal fibroblasts are the main cells of extracellular matrix in skin tissue,and have been proved to play vital roles in the formation of biological seal.This work is to explore more effective ways to promote fibroblasts adhesion,proliferation and generation of extracellular matrix for the formation of an early stable closure,then strengthen the long-term stability of maxillofacial implants.