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Human farnesyl pyrophosphate synthase(hFPPS)is known to produce farnesyl pyrophosphate,which is an isoprenoid essential for a variety of cellular processes,such as mevalonate pathway.The enzyme hFPPS has also been well established as the molecular target of the nitrogen-containing bisphosphonates(N-BPs),which are best known for their antiresorptive effects in bone and their anticancer properties.