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Due to the importance of cell migration to a diverse range of physiological and pathological processes,including angiogenesis,wound healing,and cancer metastasis,there has been enormous research interest in developing sophisticated platform that can study and control cell migration.It is now widely accepted that the mechanical interaction between cell and the extracellular matrix(ECM)can direct many important cell behaviours especially the cell migration process,but the dynamic and quantitative analysis of cell-ECM interactions are hard to achieve using the conventional microfluidics-based platforms.Hence it is valuable to fabricate a cell migration study platform in which the cell-ECM interactions can be dynamically tracked and quantified.Here,I will present our recent development in using cellular nanomechanical forces to map the cellular migration.By integrally considering the correlation between cell-ECM interactions information obtained and the biochemical signaling,we find an efficient way to regulate cell migration and may get substantial insights into the mechanism investigations of migration-related pathological processes.