The present study was conduct to compare different oral administration of medication to induce sedation in dogs.In the domestic dogs,the drugs of tiletamine-zolazepam and acepromazine(TZA) through oral administration were used to induce sedation in dogs.Three administration methods were in order directly feeding liquid drugs,encapsulated drugs and liquid drugs mixed with cooked gravy.In the domestic dogs(n =6),the results showed that the time to sedation score of 4(sternal recumbency,reluctant to stand) and the capture ratio of dogs in three administration methods were 23±25 min and 83％,27±20 min and 83％,56±27 min and 100％.The time to sedation score of 5(lateral recumbency,unable to maintain sternal recumbency) and the capture ratio of dogs in three administration methods were 53±22 min and 67％,32±20 min and 83％,730±25 min and 100％,respectively.In the field dogs,17 of 27 dogs feed the TZA drug mixed with cooked gravy or packaged into aspic achieved sedation score of 4 and further successfully captured.In conclusion,the drugs of tiletamine-zolazepam and acepromazine(TZA) through oral administration could be safely and successfully captured the dog in field,and furthermore the palatability of drugs would apparently affect the capturing rates.