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Disclosure: Patrick J Strollo, Jr., MD Research Support · Federal-R01 HL107370-RO1 DK096028-02-RO1 HL120354-01A1-1UH2HL125103-01-5UL1TR000005-09· State-PA DOH MD-02-384· Industry-Research G rant Philips-Respironics, Inc.-Research Grant ResMed, Corp.-Inspire Medical Systems-National Football League-PtnMed· Foundation-American Sleep Medicine Foundation Industry advisory:-ResMed-Phillps-Respironics-Emmi Solutions-Jazz Pharmaceuticals Outline· The Clinical Problem· Strategies and Evidence· Areas of Uncertainty· Conclusions and Recommendations