MicroRNA Regulation of Oncolytic Herpes Simplex Virus Type 1 for Selective Killing of Prostate Cance

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户：oo2009123456

【摘要】

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【作者】

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William Wei-guo Jia Cleo Y.F.Lee Paul S.Rennie

【机构】

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University of British Columbia Canada

【出处】

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中国上海第七届国际新药发明科技年会

【发表日期】

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2009年1期

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　　Purpose:Advanced,castration-resistant prostate cancer,for which there are few treatment options,remains one of the leading causes of cancer death.MicroRNAs (miRNAs) have provided a new opportunity for more stringent regulation of tumor-specific viral replication.The purpose of this study was to provide a proof of principle that microRNA-regulated oncolytic HSV-1 virus can selectively target cancer cells with reduced toxicity to normal tissues.

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MicroRNA Regulation of Oncolytic Herpes Simplex Virus Type 1 for Selective Killing of Prostate Cance

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