【摘 要】
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目的 Chronic obstructive pulmonary disease(COPD)is characterized by chronic lung inflammation,emphysema and persistentairflow limitation.Oxidative stress is a major contributing factor in the pathogenes
【机 构】
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Dept of Respiratory Medicine,Shanghai General Hospital,Shanghai Jiao Tong University
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
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目的 Chronic obstructive pulmonary disease(COPD)is characterized by chronic lung inflammation,emphysema and persistentairflow limitation.Oxidative stress is a major contributing factor in the pathogenesis of COPD.We assessed the effect of a single3-hour and of a 12 3-hour exposures over 6 weeks to ozone using micro-CT,pulmonary function test and histological analysis.方法 C57/BL6 mice were exposed to ozone or filtered air for single time or over 6 weeks.C57/BL6 mice were exposed to ozone(2.5ppm,3 hours)or filtered air for single time or over 6 weeks.Micro-Computed Tomography(Micro-CT),lung function test,bronchoalveolar lavage,blood collection,histology and immunohistochemical analysis of lung tissue were performed.
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