【摘 要】
:
The mitochondrial protein VDAC1 functions in both cellular metabolism and mitochondria-mediated apoptosis.Given these roles,we have developed VDAC1-based cancer therapies designed to disrupt metabolis
【机 构】
:
Ben-Gurion University Israel
论文部分内容阅读
The mitochondrial protein VDAC1 functions in both cellular metabolism and mitochondria-mediated apoptosis.Given these roles,we have developed VDAC1-based cancer therapies designed to disrupt metabolism or induce apoptosis.
其他文献
Oxidative damage might trigger chronic inflammation and carcinogenesis by excessive production of reactive oxygen species (ROS).In the Japan Public Health Center-based Prospective (JPHC) Study,36,745
Emerging evidences suggest that GSTM1 and GSTT1 are involved in the detoxification of carcinogens,and polymorphisms in this gene that result in a loss of enzyme activity may increase the risk of renal
Purpose: To date,studies investigating the association between dairy consumption and breast cancer in women have produced conflicting results.As diet is an important,modifiable factor affecting cancer
Our system to produce antibodies is critical for our survival against numerous infections,but it causes also many tumors.How class switch recombination and somatic hypermutation are targeted is key to
Colorectal carcinogenesis (CRC) involves a plethora of events resulting in both genomic and chromosomal instabilities.Uncontrolled proliferation and genomic instability point to the DNA repair and DNA
Molecular perception in the gastro-intestinal tract is responsible for the detection of ingested harmful drugs and toxins.We have tested associations between 25 taste receptor SNPs and the perception
Not only the accumulation of mutations but also the inhibition of cell death plays an important role in carcinogenesis.We previously reported that 8-oxoguanine accumulation in nuclear and mitochondria
While cisplatin is a commonly used drug for cancer treatment by crosslinking DNA,leading to apoptosis of cancer cells,resistance to cisplatin treatment often occurs,leading to relapse.
Alkylating agents are powerful first-line therapeutics for the treatment of malignant gliomas and metastatic melanomas.Although they alkylate DNA at several sites,the minor product O6-alkylguanine rep
Colorectal cancer (CRC) is one of the most common malignancies in the world.Previous studies have investigated the altered expression of regenerating islet-derived 3 alpha (REG3A) in various cancers.