Prion disease,such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy,is a kind of fatal neurodegenerative disease that affects many mammals including humans,and is caused by the misfol
The homeostasis of zinc is fundamentally important in the CNS to ensure many physiological processes,but dyshomeostasis and accumulation of zinc are observed in the brain of patients with Alzheimers d
Parkinsons disease(PD)is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),characteristic motor symptoms and cognitive impairment.
Metastatic breast cancer has high rates of relapse and mortality.The transcription factor hypoxia-inducible factor(HIF)plays a crucial role in breast cancer metastasis by inducing hundreds of the down
Ribonucleotide reductase(RNR),composed of RRM1 and RRM2 subunits,catalyzes the rate-limiting step in the de novo synthesis of deoxyribonucleotides triphosphate(dNTP)needed for DNA synthesis.
As an incretin used to treat type 2 diabetes,glucagon-like peptide 1(GLP-1)improves cardiovascular diseases by regulating the heart rate and blood pressure and ameliorating endothelial function and va
Type-2 diabetes is a metabolic disease.This study has revealed that the activity of serum thioredoxin(Trx)appears as a good biomarker for type-2 diabetes.
Non-muscular myosin heavy chain IIA(NMMHC IIA)plays a key role in tissue factor expression and venous thrombosis.Natural products might inhibit thrombosis through effects on NMMHC IIA.
Anthrax lethal toxin(LT)is known to induce NLRP1B inflammasome activation and pyroptotic cell death in macrophages from certain mouse strains in its metalloprotease activity-dependent manner,but the u