【摘 要】
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1.Objectives Radiation-induced adaptive response (AR) is a phenomenon manifesting as a priming low-dose-induced resistance to a subsequent challenge exposure at higher doses.Investigations of AR are e
【机 构】
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National Institute of Radiological Sciences,Japan
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1.Objectives Radiation-induced adaptive response (AR) is a phenomenon manifesting as a priming low-dose-induced resistance to a subsequent challenge exposure at higher doses.Investigations of AR are expected to provide an important scientific basis for radiation risk estimates,protection and practical applications.AR has been demonstrated in a variety of in vitro and in vivo systems.In the in vitro studies,AR was reported to induce reduction of cell death,chromosomal aberrations,mutations and malignant transformation.Among the in vivo investigations,the mouse AR model (Yonezawa Effect) was characterized by significantly decreased mortality in the 30-day survival test.
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