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Myeloid-derived suppressor cells (MDSCs) play an important role in down-regulating the functionof T cell responses.However,little is known regarding the characteristic of MDSCs in chronic hepatitisC (CHC) patients.Here,we characterized the MDSCs in two cohorts of patients.The cross-sectionalgroup included 61 treatment-naive CHC patients,14 developed rapid virological response (RVR) and22 achieved early virological response (EVR);the longitudinal group composed by 13 RVR and 10EVR with genotype 1b undergoing peg-interferon-α/ribavirin treatment.