Pre-and post-synaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户:wolfalone0319
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The present study investigated the modulation by beta-adrenoceptors (beta-AR s) of excitatory synaptic transmission in layer Ⅴ/Ⅵ pyramidal neurons of the rat medial prefrontal cortex (mPFC),using whole-cell patch clamp recording.Isoproterenol (ISO),a selective beta-AR agonist,induced a significant increase in the frequency of spontaneous excitatory post-synaptic currents (sEPSCs) and miniature excitatory post-synaptic currents (mEPSC s),which could be blocked by the beta-AR antagonist propranolol.The ISO facilitation of the frequency of mEPSCs no longer appeared when the voltage-gated Ca2+ channel blocker cadmium was pre-administered.ISO significantly enhanced the evoked excitatory post-synaptic currents (eEPSCs) mediated by non-NMDA receptors and NMDA receptor.It also enhanced the currents induced by pressure-or bath-applied NMDA.The ISO facilitation of NMDA-R mediated eEPSC and NMDA-induced current was partly or completely blocked in the presence of Rp-cAMPS,a protein kinase A (PKA) inhibitor.ISO induced a marked decrease in the paired-pulse facilitation of the non-NMDA-R and NMDA-R mediated eEPSCs.The present study provides the first electrophysiological demonstration that activation of beta-AR s facilitates excitatory synaptic transmission in the mPFC through both pre-and post-synaptic mechanisms.
其他文献
美国平均每年有超过14万人罹患大肠直肠癌,因此美国癌症协会建议从45岁起应该接受大肠镜检查.接受大肠镜检查是一项不舒服的就医过程,日本仙台大学进行一项研究发现,在检查前
期刊
“古道西风瘦马,小桥流水人家”,那里有永远值得怀念的童真童趣;乡愁是一生的根脉,树高千丈,叶落归根,那里有祖宗的墓地,父母的气息;乡愁是永恒的基因,是童年的记忆,“人言落
期刊
人工流产术前应用利多卡因子宫颈旁注射的效果广东深圳市福田人民医院黄国华我院对人工流产吸宫术前宫颈旁注射利多卡因进行了观察,了解用药后对手术的影响。临床资料1.一般资料
目的 对冠心病介入术患者实施延续性护理,观察患者自我管理水平情况.方法 对我院2019年4月~2020年4月间收治的70例冠心病介入术患者进行回顾性分析,根据护理方案的不同分为延
目的 探讨集束化综合管理结合袋鼠式护理对住院新生儿神经行为、喂养情况情况的影响.方法 选择2018年3月至2020年7月住院的新生儿100例为研究对象,随机数字表法分组,对照组50
  The paraventricular nuclues of the hypothalamus (PVN) is a central site for the integration of the neuroendocrine system and the autonomic nervous system.Th
会议
通过对多种型号等离子电视(PDP)的维修中发现,PDP屏的X驱动板电路、信号处理板电路(包括数字信号处理板电路和模拟信号处理板电路)、电源板电路的故障率相对较高,而Y板电路、
  Humoral regulatory mechanisms of hormones secretion in the anterior pituitary (AP) are considered to be significant in neuroendocrinology.But some researche
会议
  Nitric oxide (NO) plays an important role in modulation of pain,cerebral ischemia,epilepsy,morphine tolerance and dependence in the central nervous system.T
会议
4.4.2 设计内容与实施步骤rn4.4.2.1 选题 队列研究的成本高、难度大,一般只用来验证病因假设,而非探索,因此选题的假设必须确切,通常是经过了现况研究和病例对照研究反复论
期刊