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Apratoxin A 是从海洋蓝藻中分离得到的具有强抗肿瘤活性的大环内酯肽类化合物，在生物体外对人鼻咽癌细胞KB 细胞和人结肠癌细胞LoVo 细胞的IC50 值分别为0.52 和0.36 nM.分子具有新颖的化学骨架，尤其是含有四个手性中心的长链脂肪酸片段Dtena.
海洋抗肿瘤环酯肽Apratoxin A 酰胺类似物的合成及构象研究
【摘 要】
：
Apratoxin A 是从海洋蓝藻中分离得到的具有强抗肿瘤活性的大环内酯肽类化合物，在生物体外对人鼻咽癌细胞KB 细胞和人结肠癌细胞LoVo 细胞的IC50 值分别为0.52 和0.36 nM.分子具有新颖的化学骨架，尤其是含有四个手性中心的长链脂肪酸片段Dtena.
【机 构】
：
上海复旦大学药学院药化教研室
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
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