论文部分内容阅读
Therapies targeting Lgr5+ stem cells hold promise for treatment of gastrointestinal diseases.Here we report that the non-muscle-myosin-Ⅱ (NMⅡ) heavy chain Myh9 accumulates at epithelial injuries in distal colon treated with dextran sulphate sodium (DSS) and tissue-specific knockout of one allele of the Myh9 gene in gut epithelium alleviates DSS-induced colonic crypt damage and acute colitis.