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  5. Design and Synthesis of Novel Allosteric MEK1 Inhibitors as Antitumor Agents

Design and Synthesis of Novel Allosteric MEK1 Inhibitors as Antitumor Agents

来源 :全国药物化学学术会议暨第四届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：xiao12112
【摘 要】
：
The Ras/Raf/MEK/ERK pathway(ERK pathway)is a member of the four distinct mitogen-activated protein kinase(MAPK)signaling pathways,which play critical roles in regulation of diverse cellular activities
【作 者】
：
Jing Sun Yan Niu Fengrong Xu Chao Wang Lei Liang Ping Xu 
【机 构】
：
Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University Health Science
【出 处】
：
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
：
2013年11期
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　　The Ras/Raf/MEK/ERK pathway(ERK pathway)is a member of the four distinct mitogen-activated protein kinase(MAPK)signaling pathways,which play critical roles in regulation of diverse cellular activities,and the members in this cascade are potential targets for antitumor agents.1 MEK is a critical node in ERK MAPK pathway,and it shows very high specificity for ERK.2 Now 12 MEK inhibitors are currently at some stage of clinical evaluation for the treatment of cancer.
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