【摘 要】
：
CUL4A and CUL4B are closely related cullin family members and can each assemble a CulIin-R1NG E3 ligase complex (CRL) and participate in a variety of biological processes.While the CRLs formed by the
【机 构】
：
The Key Laboratory of Experimental Teratology,Ministry of Education and Institute of Molecular Medic
【出 处】
：
2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
CUL4A and CUL4B are closely related cullin family members and can each assemble a CulIin-R1NG E3 ligase complex (CRL) and participate in a variety of biological processes.While the CRLs formed by the two cullin members may have common targets, the two appeared to have very different consequences when mutated or disrupted in mammals.We here investigated the roles of cul4a and cul4b during zebrafish embryogenesis by using the morpholino knockdown approach.
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