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Purpose:This study aims to clarify what genetic and environmental factors affect life satisfaction.Methods:Life Satisfaction Index-A (LSI-A) of the 18-item version was employed as the outcome measurement in elderly twins.The subject of this study was 1,008 twins who participated in the Osaka University Aged Twin Registry (OUATR).These participants include 699 male and 309 female,as well as 719 MZ and 289 DZ,whose mean age is 70.6 (±11.9).