【摘 要】
：
表观遗传学是分子遗传学研究的一个热点,DNA甲基化作为细胞记忆的一种机制,在维持正常细胞功能、遗传印记以及肿瘤发生中发挥着重要作用,是表观遗传学的核心领域之一。本
【机 构】
：
辽宁省沈阳市皇姑区崇山中路66号辽宁大学环境学院沈阳110036
【出 处】
：
第六届亚洲特大城市环境与公共健康论坛暨中国环境科学学会环境医学与健康分会2015年会
论文部分内容阅读
表观遗传学是分子遗传学研究的一个热点,DNA甲基化作为细胞记忆的一种机制,在维持正常细胞功能、遗传印记以及肿瘤发生中发挥着重要作用,是表观遗传学的核心领域之一。本文概述了DNA甲基化的相关机制,其中包括DNA甲基化模式特点及参与其改变与维持的酶类,同时对DNA甲基化分析的方法,即高效液相色谱法(High performance liquid chromatography, HPLC)、甲基化敏感的扩增片段长度多态性法(Metyhlation sensitive amplified fragment length polymorphism,MSAP)、亚硫酸氢盐测序法(bisulfate mapping)以及甲基化芯片法(DNA methylation chip technology)进行详尽的介绍和讨论。
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