【摘 要】
：
Soluble Guanylate Cyclase (sGC) is the core enzyme in the NO/cGMP signal pathways.It can be classified as two types: sGC1 and sGC2.Ns-HNOX is a heme protein which has a 35％ sequence identity and high
【机 构】
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Key Laboratory for Molecular Enzymology & Engineering of the Ministry of Education, School of Life S
【出 处】
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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
Soluble Guanylate Cyclase (sGC) is the core enzyme in the NO/cGMP signal pathways.It can be classified as two types: sGC1 and sGC2.Ns-HNOX is a heme protein which has a 35％ sequence identity and high structure homology to the β subunit of sGC.In previous work, we have reported the presence of two heme pocket conformations in CO-bound bovine soluble Guanylate Cyclase, and the effect of different subtract.The results indicate the GTP-induced structural changes in sGC in the presents of CO and YC-1.
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