【摘 要】
：
The present study was carried out to investigate the antidiabetic properties of aqueous stem bark extract ofA.africana and its beneficial effect on haematological parameters in streptozotocin induced
【机 构】
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Phytomedicine Research Centre University of Fort Hare South Africa
【出 处】
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BIT`s 1st Annual International Symposium of Hematology-2012(
论文部分内容阅读
The present study was carried out to investigate the antidiabetic properties of aqueous stem bark extract ofA.africana and its beneficial effect on haematological parameters in streptozotocin induced diabetic rats.A total of 30 rats, 24 diabetic and 6 normal rats were used for this study.Diabetes was induced in male Wistar rats by intraperitoneal injection of streptozotocin.After being confirmed diabetic, animals were orally treated with distilled water or extracts at 100 or 200 mg/kg body weight daily for 10 days.The haematological parameters including red blood and white blood cells and their functional indices were evaluated in diabetic treated groups compared with the controls.The extract at the doses investigated significantly reduced the blood glucose levels while the best result was obtained at 200 mg/kg body weight.The feed and water intake in diabetic rats was significantly reduced while weight loss was minimized at both dosages.Similarly, the levels of red blood, white blood cells and their functional indices were significantly improved after extract administration at both doses.The data obtained in the present study showed that the aqueous bark extract of A.africana possess antihyperglycemic properties.In addition, the extract could prevent various complications of diabetes as well as improving some haematological parameters.Further experimental investigation is needed to exploit its therapeutic relevant to substantiate its ethnomedicinal usage.
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