Micro/nano-scale technologies can have a significant impact on medicine and biology in the areas of cell manipulation,diagnostics and monitoring.At the convergence of these new technologies and biology,we research for enabling solutions to the real world problems at the clinic.Emerging nano-scale and microfluidic technologies integrated with biology offer innovative possibilities for creating intelligent,mobile medical lab-chip devices that could transform diagnostics and monitoring,tissue engineering and regenerative medicine.In this talk,we will present an overview of our laboratorys work in these areas focused on applications in point-of-care and primary care settings including applications for ovarian cancer detection from urine,rapid CD4 counts for global health,multiple pathogen detection with a focus on viral load from unprocessed whole blood and bedside peritonitis detection for end-stage kidney disease patients going through peritoneal dialysis therapy.These emerging technologies could shape our future creating broadly applicable platforms for scientific discovery,providing clinical solutions for resource-constrained settings in the developing world as well as for primary care settings in the developed world.