Ubiquitin degradation of ULK1 by ERK1 and GSK-3β cooperatively attenuates mitophagy and promotes tum

来源 :2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：peterstone138

【摘要】

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【作者】

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Xiao-Qi Wu Gong-Kan Feng Yi-Xin Zeng Xiao-Feng Zhu Shan Jiang Rong Deng Jun Tang Wen-Dan Chen Jiao Ji Zi-Ming Du Dan-Dan Li Shu-Peng Chen

【机构】

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State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-Sen University,Guangzhou 51006

【出处】

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2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会

【发表日期】

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2014年5期

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　　The modulation of autophagy is an important component of tumor initiation and progression and ULK1 plays an essential role in macroautophagy and mitophagy.However, the precise regulatory signaling mechanisms and functions of ULK1 in cancers are not completely understood.Here, we find that the expression of ULK1 decreases gradually during the progression of breast cancer.A strong correlation between low expression of ULK1 and ERK, GSK-3β activation is observed in human breast carcinoma.

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