DKK1或通过启动子甲基化来实现表观遗传下调发挥促进肿瘤作用

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：a77115280

【摘要】

：

目的 Dickkopf相关蛋白1(DKK1)作为Wnt信号通路抑制剂是胃癌发生发展中重要的分子，既往研究证实DKK1的启动子甲基化是胃癌患者生存率低的独立危险因素。胃黏膜肠上皮化生是胃癌重要的癌前病变阶段，也是临床上重要的干预治疗时间窗，但目前肠上皮化生的发生机制未完全明确。

【作者】

：

陆文全倪阵韩川袁挺张剑冯晨晨贺琪李丹张丽峰吴琼宁寒冰时永全

【机构】

：

空军军医大学西京医院;郑州大学第一附属医院空军军医大学西京医院;中国人民解放军西部战区总医院

【出处】

：

2019中国肿瘤学大会

【发表日期】

：

2019年7期

【关键词】

：

DKK1 癌前病变甲基化肠上皮化生 GIM

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DKK1或通过启动子甲基化来实现表观遗传下调发挥促进肿瘤作用

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