心力衰竭是由任何心脏结构或功能异常导致心室充盈或射血能力损伤的一组复杂临床综合征。据统计,全球25-75 岁人群中,慢性心力衰竭发病率为3%,发病率高、治疗费用高、死亡率高,已成为严重影响人类健康和生活质量的疾病。
蛋白酪氨酸磷酸酶SHP2 在细胞信号转导过程中起着重要的作用,参与细胞的生长、分化、代谢、运动和凋亡,作为潜在的抗肿瘤治疗靶点备受关注1.选择性抑制剂能为研究SHP2 在细胞信号通路中的生物功能及作用机制提供工具化合物,为抗肿瘤药物研究先导化合物2.
Small molecules that can selectively ablate cancer stem cells(CSCs)are very rare.Here we report a series of SLs and their derivatives that can selectively eradicate AML stem cells.Micheliolide(MCL)was
传统中药蟾酥具有抗肿瘤、强心、中枢神经兴奋、局麻以及抗炎等作用[1]。现代研究发现以沙蟾毒精、蟾毒灵和酯蟾毒配基为代表的蟾毒内酯类化合物是其发挥抗肿瘤作用的主要活性成分。
It is widely reported that cancer stem cells play a key role in carcinogenesis,cancer disease progression,relapse,and drug resistance.However,compounds that selectively inhibit CSC growth are rarely r
Rakicidin A is a cyclic depsipeptide that has exhibited unique growth inhibitory activity against chronic myelogenous leukemia stem cells.Furthermore,rakicidin A has five chiral centers with unknown s
Objective To investigate the effects of preoperative prehabilitation protocol on clinical outcomes of gastric cancer patients with MetS underwent laparoscopic radical gastrectomy and to explore the re
目的 探讨胃癌患者术中所需切除的合理近切缘距离(PM),基于PM 及术前临床资料建立远端胃癌患者预后的列线图预测模型.方法 回顾性分析南方医院普通外科2004 年6 月至2014 年6 月704 例行远端胃癌根治术患者的临床病理资料,通过分析PM(以0.5cm 递增)与患者预后的关系,将其划分为PM1≤2.0 cm,n=90;PM2:2.1-5.0 cm,n=462;PM3>5.0 cm,n=15