PROX1 REGULATES INVASION AND VIRAL GENE EXPRESSION IN LYMPHATIC ENDOTHELIAL CELLS

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：zb_jinzhen

【摘要】

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By utilizing a 3D cell culture model for KSHV-infected lymphatic endothelial cells (LECs) we recently showed that KSHV reprograms lymphatic endothelial cells in

【作者】

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Elisa Kaivanto Markus V.Vaha-Koskela Raquel Diaz Martinez Jianpin Cheng Ville Rantanen Sampsa Hautaniemi Kari Alitalo Kaisa Lehti Tatiana Petrova Paivi M.Ojala

【机构】

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ResearchPrograminCellandMolecularBiology,InstituteofBiotechnology,UniversityofHelsinki,FinlandResear

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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By utilizing a 3D cell culture model for KSHV-infected lymphatic endothelial cells (LECs) we recently showed that KSHV reprograms lymphatic endothelial cells into a mesenchymal, invasive cell type via endothelial-to-mesenchymal transition.Transcriptome analysis of the KSHV-reprogrammed cells revealed substantial enrichment of invasion related genes including matrix metalloproteinases MMP14 (gene for MT1-MMP) and MMP1 with a concomitant decrease in PROX1, the master regulator of lymphatic cell fate, expression.

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PROX1 REGULATES INVASION AND VIRAL GENE EXPRESSION IN LYMPHATIC ENDOTHELIAL CELLS

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