【摘 要】
：
RNA interference (RNAi) is emerging as one of promising strategies for tumor therapy, especially for inhibiting tumor metastasis.However, an efficient and safety non-virus delivery system for clinical
【机 构】
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Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical Colle
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
RNA interference (RNAi) is emerging as one of promising strategies for tumor therapy, especially for inhibiting tumor metastasis.However, an efficient and safety non-virus delivery system for clinical siRNA therapy is still a major challenge.Clinical applications of cationic non-viral vectors are limited because of their low transfection efficiency, especially in the serum containing mediums and in vivo conditions.The difficulty of lysosome escape and nonspecific adsorption of serum proteins are considered the main reasons.In this talk, Id like to introduce several recent approaches developed by our group to overcome these barriers for siRNA delivery.
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