Determining the in-situ immune status of diseased organs is mostly subject to visual estimation, or-at best-to manual counting.Hence, experts usually have the choice of the "least of evils" between guessing and endless (manual) counting.In tumor immunology, infiltrating inflammatory cells need to be phenotypically characterized on a quantitative basis.To better understand the function of inflammatory cells in tumor development, type and number of inflammatory cells and their proximity to glandular/tumor structures have to be analyzed in-situ and correlated with disease state.