Altemative splicing is a major driving force for expanding proteomic diversity that allows expression of protein variants critical for cell-or tissue-specific functions from a single gene.Splicing regulation is primarily achieved by the association of splicing factors with specific splicing elements on the pre-mRNA that determines whether to include or exclude an alternative exon.Alterations in splicing factors or mutations in their target sequences result in dysregulated splicing products, which have been implicated in a wide range of human diseases.