【摘 要】
：
Emerging evidence indicates that human mesenchymal stem cells (hMSCs) can be recruited to tumor sites, and affect the growth and development of human malignancies.However, there is some controversy re
【机 构】
：
Provincial Hospital Affiliated to Shandong University China
论文部分内容阅读
Emerging evidence indicates that human mesenchymal stem cells (hMSCs) can be recruited to tumor sites, and affect the growth and development of human malignancies.However, there is some controversy regarding their effects on tumor progression.One opinion is that MSCs promote tumor progression and metastasis, while another notion is that MSCs suppress tumor growth.This discrepancy may be due to differences in tumor models, the heterogeneity of MSCs, the dose or timing of MSCs treated, or other unknown factors.Therefore, further studies addressing the relationship between mesenchymal stem cells and tumor development are necessary, which may strengthen our recognition to the mechanism of tumor development.
其他文献
Bone defects resulting from trauma or rebsorption, whether physiological or pathological, remain a major challenge in the management of patients.Non-union fractures and aseptic bone necrosis are two p
The regeneration and repair of articular cartilage after the evolution of four generation technology.The first generation of technology as the periosteum overlying cartilage defect, then inject amplif
Lgr5 has been approved to be the stem cell marker in mouse gastrointestinal tract.Evidences also show that Lgr5+ and Bmi1+ cells may represent two stem cell sub-populations with different functions in
The esbablishrnent of human embryonic stem cells, and lately, induced pluripotent stem cells (hESC, hiPSC, respectively) greatly expanded our view to subtly analyze the cellular and molecular happenin
Clostridium difficile (Cd) is a well known emerging pathogen of opportunistic infection in hospitals worldwide and is the major causative antibiotic-associated pseudo-membranous colitis and diarrhea i
The development of the stem cell therapy has been recognized for solving various rare and incurable diseases that modem medicine has not solved yet.Over the past 10 years of hard work and investment i
Recent studies have revealed that following injuries, soft tissues such as anterior cruciate ligaments (ACL), release large amounts of matrix metalloproteinases (MMPs).These enzymes have a devastating
In bone tissue engineering and regeneration we have generated a unique transgenic mouse line, in which luciferase and GFP reporters are driven by a bone specific gene promoter and an actin promoter, r
Although induced pluripotent stem cells (iPSCs) can be reprogrammed from human somatic cells using four defined factors, the process is extremely inefficient, as there is a strong epigenetic block pre
Objective: To investigate the efficiency ofautologous transplantation of peripheral blood stem cells for treatment of patients with diabetic lower limb ischemia.Methods: Eighteen patients of type 2 di