Nanobiomaterials can play a central role in regenerative medicine and tissue engineering by facilitating cellular behavior and function,such as those where extracellular matrices(ECMs)direct cell morphogenesis,proliferation,differentiation and apoptosis.However,controlling cell proliferation and differentiation using matrices from natural sources is still challenging due to complex and heterogeneous culture conditions.New biological materials of recombinant protein are now being developed using common genetic engineering to create well-defined,multifunctional materials.In recent years,the recombinant protein materials with tissue engineering applications have been studied including structural protein,growth factor and cell-bind protein.