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Background HLS5 belongs to the RBCC (Ring-finger, B-box, coiled-coil) family, a family of tumor suppressive genes including Pm, Tif1-α ,Herf and Rfp, it has been reported to regulate erythroid differentiation,to be activated during the conversion of J2E erythroleukemic cells to monocytoid cells, and assumed to be a tumor supressor.However, the role of HLS5 in acute lymphoblastic leukemia has never been explored.