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5. The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to

The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to

来源 :中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：xingzhewei1123

【摘 要】

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Objectives: Phosphatidylinositol-3 kinase (PI3K)/Akt signaling represents a key survival mechanism in cancer cells and has emerged as an attractive cancer therapeutic target.NVP-BKM120 (BKM120) is a n

【作 者】

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Hui Ren Mingwei Chen Liqun Zhao Yikun Li Ping Yue Shiyong Sun 

【机 构】

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First Affiliated Hospital of Medical College of Xian Jiaotong University, Xian, Shaanxi, P.R.China

【出 处】

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中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议

【发表日期】

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2013年2期

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Objectives: Phosphatidylinositol-3 kinase (PI3K)/Akt signaling represents a key survival mechanism in cancer cells and has emerged as an attractive cancer therapeutic target.NVP-BKM120 (BKM120) is a new pan class Ⅰ PI3K inhibitor that suppresses this pathway.

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