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Background: Nasopharyngeal carcinoma(NPC)is prevalent in Southern China.Remarkably high incidence of NPC is observed in Guangdong province and Hong Kong.Combined treatment with cisplatin and radiotherapy showed noticeable survival benefits to the patients especially in advanced cases.The inflammatory tumor microenvironment is a determining factor to cisplatin sensitivity.Recent studies demonstrate that cisplatin can induce inflammatory factor PTX3(long pentraxin 3)which may contribute to drug resistance and treatment failure.