【摘 要】
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To identify gene expression abnormalities in schizophrenia (SZ) ,we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset
【机 构】
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Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University
【出 处】
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中华医学会第十七次全国行为医学学术会议
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To identify gene expression abnormalities in schizophrenia (SZ) ,we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls.We detected 84 transcripts differentially expressed by affection status,with 82 genes being upregulated and 2 downregulated.We identified two gene coexpression modules (green and red) associated with SZ,including 446 genes altogether.The green module is positively correlated with SZ, encompassing predominantly over-expressed genes in SZ;while the red module was negatively correlated with disease status, involving mostly nominally under-expressed genes in SZ.CCDC 134, UBD, C 10orf67, ABIN-3, and ZIC2 are hub genes in the coexpression modules, while protein-protein interaction analysis suggests AKT1 ,CHEK1 and BRCA1 as hub genes.Our findings indicate that mRNA coexpression abnormalities may serve as a promising mechanism underlying the development of SZ.
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