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Objectives Hemodynamics parameter of left main coronary artery (LMCA) were studied in LDL-R-/-mice by using Ultrasound biomicroscopy (UBM), and to evaluate the influence of atherosclerosis to the hemodynamics of coronary artery, and the value of UBM in the application.By measuring maximum IMT in the ascending aorta, UBM was capable of following progression of atherosclerosis in AS models mice.