A powerful score-based test statistic for detecting gene-gene co-association

来源 :泛华统计学会(icsa)2015年学术会议 | 被引量 : 0次 | 上传用户:nihao136
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The genetic variants identified by Genome-wide association study(GWAS) can only account for a small proportion of the total heritability for complex disease.
其他文献
Recurrent event data arise frequently in longitudinal medical studies.In many situations,there are a large portion of subjects without any recurrent events,mani
会议
Under the case-cohort design introduced by Prentice(1986),the covariate histories are ascertained only for the subjects who experience the event of interest(i.e
会议
Proportional hazards(PH) assumption is often used in designing clinical studies with time to event as the primary endpoint.The log-rank test is the most commonl
会议
The cure rate model is most useful for designing studies with time-to-event endpoints such as Overall Survival(OS),when a plateau is reached in the survival cur
会议
会议
For most oncology studies,the long-term survival outcome is a typical endpoint for large-scaled confirmatory(phase Ⅲ) studies,while some short-term outcome(e.g
会议
Multivariate panel count data occur in many fields such as medical and social science studies in which several outcomes of interest are measured simultaneously
会议
Event history studies occur in many fields including economics,medical studies and social science.In such studies concerning some recurrent events,two types of
会议
  Background: With the advance of next generation sequencing technologies,identifying rare variants associated with phenotypes of interest has become feasible
会议