2. 您的位置
3. 首页
4. 会议论文
5. Untargeted screening of nerve agents and its degradation products using UHPLC Q-Orbitrap mass spectr

Untargeted screening of nerve agents and its degradation products using UHPLC Q-Orbitrap mass spectr

来源 :2018年中国质谱学术大会 | 被引量 : 0次 | 上传用户：chren1981

【摘 要】

：

Nerve agents(NAs)are a kind of notorious chemical warfare agents with great threat to national security and public health,which traditionally classified into two classes of G and V agents.

【作 者】

：

Meijuan Zhang Bin Xu Jianwei Xie 

【出 处】

：

2018年中国质谱学术大会

【发表日期】

：

2018年7期

【关键词】

：

UHPLC/ Q-Orbitrap Nerve agents Untargeted screening IS-CID MS 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Nerve agents(NAs)are a kind of notorious chemical warfare agents with great threat to national security and public health,which traditionally classified into two classes of G and V agents.

其他文献

表面等离子体共振-介质阻挡放电质谱的联用

表面等离子体共振(SPR）技术能够获得分子间相互作用的有关动力学和热力学信息,被广泛用于物质相互作用的研究中.但SPR实验难以提供被测物质的结构数据,这将其应用范围限制在了已知物质的检测研究中,难以用于涉及未知化合物的相互作用体系.

会议

介质阻挡放电离子源表面等离子体共振质谱接口

Rapid Protein Analysis of Limited Mammalian Cells by Microwell-based Liquid Chromatography-Mass Spec

Cellular differences always exist to certain degree in any cell populations,while conventional proteomic techniques reveal averaged information from a minimum of thousands of cells.

会议

sample processingmass spectrometryproteomicsprotein enrichment

植物中羟基肉桂酸酰胺的液相色谱-高分辨质谱深度注释方法研究

羟基肉桂酸酰胺来自类苯基丙烷代谢通路，是植物体内普遍存在的一类次生代谢物。羟基肉桂酸酰胺在植物的生长发育过程中发挥着重要的作用。鉴于该类物质具有结构多样性、化学多样性和种属、组织分布特异性，目前已有的羟基肉桂酸酰胺分析方法仅适合分析给定植物种类/组织中一些已知的羟基肉桂酸酰胺。

会议

羟基肉桂酸酰胺深度解析in silico UHPLC-HRMS数据库结构保留预测模型

同位素标记结合超高效液相色谱-串联质谱分析神经类固醇

帕金森病(Parkinsons disease,PD)是一种多发于中老年人的神经退行性疾病,有报道证明神经类固醇及其代谢物含量的变化与PD 密切相关,因此发展神经类固醇的高效高灵敏分析方法具有重要意义[1,2]。

会议

神经类固醇同位素标记衍生液相色谱-质谱灵敏度提高帕金森病

Quantitative Chemoproteomic Profiling 4-Hydroxynonenal Modified Proteins

4-hydroxynonenal(HNE)modified proteins are closely associated with cellular dysfunctions and biological metabolic process.

会议

HNE-modified proteinclick chemistryMRM validationquantification

同位素标记-磁固相萃取UHPLC-MS/MS分析含羟基的胆固醇代谢物与药物分子

含羟基的胆固醇和代谢物(HCM)是阿尔茨海默病(AD)的潜在生物标志物。因此,体内HCM 的定量分析可以作为早期临床诊断的指标[1,2]。然而,由于生物样品中HCM 含量极低,而且样品基质复杂,导致其定量检测仍然面临巨大挑战。

会议

同位素标记衍生化羟固醇液相色谱-串联质谱阿尔茨海默病药效评价

Lipid profiling of single lipid droplets in HepG2 cells by using nanospray mass spectrometry(nano-ES

Lipid droplets(LDs)have been attracting more attention due to its crucial role in energy reservoir and lipid metabolism.

会议

Single lipid dropletLipid profilingnano-ESI MS

Simultaneous Determination of Abscisic Acid and Its Catabolites by Hydrophilic Solid-phase Extractio

Abscisic acid(ABA),is a phytohormone,playing a signaling and regulating role in plant growth and development processes,e.g.seed development,organ formation,senescence,abscission,inhibition of precocio

会议

Abscisic acidCatabolitesHydrophilic solid-phase extractionMass spectrometryS

Spatio-temporal profiling of abscisic acid,indoleacetic acid and jasmonic acid in single rice seed d

Abscisic acid(ABA),indoleacetic acid(IAA)and jasmonic acid(JA)are plant hormones that were reported to play indispensable roles during seed germination [1-3].

会议

Derivatization reagentspatio-temporal profilingplant hormonesdensity function

Sensitive and accurate determination of trehalose-6-phosphate in plant tissues by chemical derivatiz

Trehalose-6-phosphate(T6P),the precursor of trehalose in the biosynthetic pathway,is an important signaling metabolite that is involved in many physiological processes [1-2].

会议

Sugar phosphateChemical derivatizationMass spectrometryHydrophilic interactio