【摘 要】
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Objective: The association between eNOS polymorphism and erectile dysfunction risk remains conflicting.We conducted a meta-analysis to examine the eNOS T894G,4VNTR,C-786T polymorphism in relation to t
【机 构】
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Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210
【出 处】
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华夏医学论坛·泌尿生殖2015暨亚太性医学年会2015
论文部分内容阅读
Objective: The association between eNOS polymorphism and erectile dysfunction risk remains conflicting.We conducted a meta-analysis to examine the eNOS T894G,4VNTR,C-786T polymorphism in relation to the susceptibility of erectile dysfimction.Methods: Studies concerning this association were searched and related information was extracted from the included studies.The STATA 12.0 software was used to perform a meta-analysis.Results: Significant association was observed between eNOST894G polymorphism and erectile dysfunction risk for all genetic models(T vs.G: OR =1.73;95%CI,1.52-1.97;P=0.000;TT vs.GG: OR =1.99;95%CI,1.40-2.84;P=0.000;TG vs.GG: OR =1.67;95%CI,1.42-1.98;P=0.000;TT+TG vs.GG: OR =1.89;95%CI,1.61-2.22;P=0.000;TT vs.TG+GG: OR =2.33;95%CI,1.69-3.22;P=0.000;TG vs.TT+GG: OR =1.47;95%CI,1.25-1.73;P=0.000).Subgroup analysis by population produced significant results in Asian population as well.The metaanalyses of 4VNTR and C-786T polymorphism yielded inconsistent results.Conclusions: In conclusion,the results of the metaanalysis indicated that the T allele of eNOS gene T894G polymorphism is a risk factor for erectile dysfunction in Asians.However,the results should be interpreted with caution and further studies are required.
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