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<正>IL-22/IL-22RA1 has been reported to play a vital role in acute and chronic panreatitis progression,via mediating crosstalk between immune cells and acinar cells or stellate cells respectively.High IL-22RA1 expression on pancreatic tumor is associated with poor patient survival,however little is know about how IL-22/IL-22RA1axis involved in pancreatic cancer development.In our study,we firstly identified IL-22RA1hppopulation harbored