【摘 要】
：
The great concern over DDT exposure and breast cancer has been aroused for few decades.With a chiral center, o,p′-DDT exerts the strongest estrogen effect among DDTs, and R-o,p′-DDT is more potent tha
【机 构】
：
Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou, China
【出 处】
：
2014华东胸部肿瘤论坛暨第七届浙江省胸部肿瘤论坛
论文部分内容阅读
The great concern over DDT exposure and breast cancer has been aroused for few decades.With a chiral center, o,p′-DDT exerts the strongest estrogen effect among DDTs, and R-o,p′-DDT is more potent than S-o,p′-DDT.However, the enantioselectivity impact on occurrence and development of breast cancer of o,p′-DDT still remains to be elucidated.In the study, o,p′-DDT could enantioselectively interfere breast cells migration and infiltration and related genes expression were evaluated in vitro MCF-7 cells.Both cells migration and infiltration were induced by o,p′-DDT,and R-o,p′-DDT had greater effect than S-o,p′-DDT.Furthermore,the mRNA expression of MMP-2,9 and hTERT were upregulated by R-o,p′-DDT exposure.Meanwhile the R-o,p′-DDT significantly inhibited the mRNA expression of TIMP-1,and TIMP-4 and cell adhesion molecules.For our knowledge,this is the first report about chiral estrogenic chemicals enantioselective impact on the development of breast cancer.Our results suggest that the estrogenic like chiral compounds are of significant concern with respect to human cancers depended by estrogen.
其他文献
目的：探讨直肠癌组织PI3K和Akt蛋白表达及与预后相关性.方法：应用免疫组织化学技术检测PI3K和Akt蛋白在60例直肠癌组织、30例直肠腺瘤组织及10例癌旁正常黏膜组织中的表达,并对60例直肠癌患者进行随访.结果：PI3K和Akt蛋白在直肠癌组织中高表达;两者呈正相关.PI3K蛋白表达水平与术前CEA水平、分化程度、临床分期、淋巴结转移和远处转移有关(P均＜0.05);与年龄、性别、肿瘤部位和
To investigate whether MDR1 polymorphisms are associated with therapeutic outcome and hematologic toxicities of taxanes-based preoperative chemotherapy in breast cancer patients.MDR1 variants were det
Breast cancer is one of the most common malignancies in women worldwide.It was estimated that in the United States approximately 192,000 female patients would be diagnosed with breast cancer and 40,00
[Baekgroud] Nomogram has demonstrated its capability in individualized estimates of survival in diverse cancers.To date, however, no nomogram has been developed for ESCC.[Methods] We retrospectively i
[Purpose] Complement component 7 (C7) is a member of the complement system,which participates in the formation of Membrane Attack Complex.People with component C7 deficiency are prone to bacterial inf
The prognostic and predictive value of CA125 and CEA in patients with non-small cell lung cancer (NSCLC) is still uncertain.We retrospectively analyzed preoperative serum CA125 and CEA in 645 operable
[Introduction] Lipids are essential building blocks for cell membranes and important components of cell signaling and regulatory molecules.Dysregulation of lipid metabolisms has been linked to several
Background:Small cell lung cancer (SCLC) includes conventional and combined SCLC.Combined SCLCs accounts for 28％ of SCLCs who were received surgical resection, but it is reported only about 1％～3％ of S
Purpose This study aims to compare treatment outcomes between stereotactic body radiation therapy (SBRT) and surgery in stage I non-small-cell lung cancer (NSCLC).Methods and Materials Eligible studie
Purpose: To re-examine the imaging characteristics of halo sign (HS) associated with solitary pulmonary nodules (SPN) for SPN differentiation with emphasis on the HS margins.Materials and methods: The