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  5. Synergistic enhancement of hepatocellular carcinoma therapy using a combination of anti-miR-181b and

Synergistic enhancement of hepatocellular carcinoma therapy using a combination of anti-miR-181b and

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：inc9649
【摘 要】
：
MicroRNAs (miRNAs) play an essential role in inhibiting hepatocellular carcinoma (HCC) via several different pathways.However, one major obstacle for its clinical application is the lack of effective
【作 者】
：
Shengnan Huang Ying Liu Weiping Wang Ningxia Zhang Jing Wang Shijin Bao Xiaojing Qiu Lijuan Yan Huanjie Li Zhenxi Niu Yurong Hu 
【机 构】
：
School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR Chin
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
Hepatocellular carcinoma MicroRNA Gold nanocage Gene therapy Photothermal therap 
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　　MicroRNAs (miRNAs) play an essential role in inhibiting hepatocellular carcinoma (HCC) via several different pathways.However, one major obstacle for its clinical application is the lack of effective miRNA delivery vectors.In this study, we have successfully loaded anti-miRNA-181b, a potent endogenous tumor suppressive molecule in HCC, into functionalized gold nanocages (PTPAuNCs) to obtain a novel tumor targeting miRNA delivery system, designated as FA/anti-miR-181b/PTPAuNCs (PTPAuNC-NPs).
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