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  5. Effects of glutamic acid on spontaneous discharges of arcuate nucleus in hypothalamic slice from nor

Effects of glutamic acid on spontaneous discharges of arcuate nucleus in hypothalamic slice from nor

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：yyw2dy2001
【摘 要】
：
To study the influence of glutamic acid (Glu) on the electric activities of arcuate nucleus (ARC) neurons in the normal rats and inflamed rats which were induced by complete Freunds adjuvant (CFA).The
【作 者】
：
Jian-Ming PENG Qi ZHU Xing-Hong JIANG 
【机 构】
：
Department of Neurobiology, Laboratory of Aging and Nervous Diseases, School of Medicine, Soochow Un
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
【发表日期】
：
2007年12期
【关键词】
：
glutamic acid (Glu) NMDA receptor MK-801 arcuate nucleus(ARC) brain slice inflam 
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　　To study the influence of glutamic acid (Glu) on the electric activities of arcuate nucleus (ARC) neurons in the normal rats and inflamed rats which were induced by complete Freunds adjuvant (CFA).The experiment was performed on isolated mediobasal hypothalamus slice to observe the effect of Glu on unit discharges of ARC neurons.The NMDA receptor agonist NMDA,NMDA receptor antagonist MK-801 and non-NMDA receptor antagonist CNQX were used to analyze the receptor mechanism of effect.The unit discharges were recorded extracellularly.The immunohistochemistry was imployed to observe the expression of NMDAR1 in the ARC neurons of normal rats and the CFA rats.The experimental results indicated that:(1) Three types of spontaneous discharge (regular firing,irregular firing,firing in bursts) were observed in ARC neurons.(2) Glu (200 μmol/L) can enhance the electric activities of ARC neurons.
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