EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise its effectiveness in lung ca

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：gaoyunlonggao

【摘要】

：

Objective Lung cancer is the most frequent cause of cancer-associated deaths worldwide,and NSCLC(non-small cell lung cancer)accounts for 80%of lung cancers.

【作者】

：

Lifeng Feng Lixian Yang Shilong Ying Muchun Li Miaoqin Chen Shiman Hu Hongchuan Jin

【机构】

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Sir Run Run Shaw hospital,School of Medicine,Zhejiang University

【出处】

：

2019中国肿瘤学大会

【发表日期】

：

2019年7期

【关键词】

：

EGFR TKIs SQSTM1 Autophagy Lysosome NSCLC

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　　Objective Lung cancer is the most frequent cause of cancer-associated deaths worldwide,and NSCLC(non-small cell lung cancer)accounts for 80%of lung cancers.

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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise its effectiveness in lung ca

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