【摘 要】
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The neurotoxicity of β-amyloid protein (Aβ) has been implicated to be related to pathogenesis of Alzheimers disease (AD).Recent evidence suggests that autophagy might be involved in the toxicity of Aβ
【机 构】
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Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 40
【出 处】
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2015全国老年痴呆与认知障碍相关疾病学术大会
论文部分内容阅读
The neurotoxicity of β-amyloid protein (Aβ) has been implicated to be related to pathogenesis of Alzheimers disease (AD).Recent evidence suggests that autophagy might be involved in the toxicity of Aβ.Hydrogen sulfide (H2S), which is identified as a new neuromodulator, plays an important protective role in the neurotoxicity of Aβ.However, the effect of H2S on autophagy of Aβ-induced is unclear.Aiming to answer this question, we examined effect of H2S on cell viability by MTT analysis,and the expression of autophagy related protein by westem blot,immunocytochemistry and Transmission electron microscopy analysis in Aβ25-35 treated Neuro-2a cells.
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